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TAU (MAPT) Antibody (S720)

APR13697G Product Datasheet Protocol

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APR13697G		100 μl / $495

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Leading Biology Inc.

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TAU (MAPT) Antibody (S720)

Brand	Leading Biology	Catalog Number	APR13697G
Product Type	Polyclonal Antibodies	Field of Research
Product Overview	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality TAU (MAPT) antibody (S720).
Molecular Weight	78928 Da
Cellular Localization	Antigen Cellular Localization: Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cell projection, axon. Note=Mostly found in the axons of neurons, in the cytosol and in association with plasma membrane components
Host	Rabbit
Species Reactivity	Human, Cynomolgus Monkey
Immunogen	699-728 aa
Target	This TAU(MAPT) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 699-728 amino acids from human TAU(MAPT).
Isotype	Rabbit Ig
Symbol	MAPTL, MTBT1, TAU
GeneID	4137
UniProt ID	P10636
Function	Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N- terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.
Summary	MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy.
Form	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Storage & Stability	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Applications	WB, IHC, IHC-P, E
Dilution	IHC~~1:25 WB~~1:1000 IHC-P~~1:10~50
Synonyms	Microtubule-associated protein tau, Neurofibrillary tangle protein, Paired helical filament-tau, PHF-tau, MAPT, MAPTL, MTBT1, TAU
Images	APR13697G staining TAU in Monkey brain tissue sections by Immunohistochemistry (IHC-P - paraformaldehyde-fixed, paraffin-embedded sections). Tissue was fixed with formaldehyde and blocked with 3% BSA for 0. 5 hour at room temperature; antigen retrieval was by heat mediation with a citrate buffer (pH6). Samples were incubated with primary antibody (1/25) for 1 hours at 37°C. A undiluted biotinylated goat polyvalent antibody was used as the secondary antibody. MAPT Antibody (pS720) (Cat. APR13697G) western blot analysis in SH-SY5Y cell line lysates (35ug/lane).This demonstrates the MAPT antibody detected the MAPT protein (arrow). Formalin-fixed and paraffin-embedded human brain tissue reacted with MAPT Antibody (S720) (Cat. APR13697G), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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