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FOXA2 Antibody (C-term)

AMM04588G Product Datasheet Protocol

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AMM04588G		100 μl / $495

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FOXA2 Antibody (C-term)

Brand	Leading Biology	Catalog Number	AMM04588G
Product Type	Polyclonal Antibodies	Field of Research
Product Overview	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality FOXA2 antibody (C-term).
Molecular Weight	48306 Da
Cellular Localization	Antigen Cellular Localization: Nucleus {ECO:0000255\|PROSITE- ProRule:PRU00089, ECO:0000269\|PubMed:14500912}. Cytoplasm. Note=Shuttles between the nucleus and cytoplasm in a CRM1-dependent manner; in response to insulin signaling via AKT1 is exported from the nucleus
Host	Rabbit
Species Reactivity	Human, Rat
Immunogen	380-407 aa
Target	This FOXA2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 380-407 amino acids from the C-terminal region of human FOXA2.
Isotype	Rabbit Ig
Symbol	HNF3B, TCF3B
GeneID	3170
UniProt ID	Q9Y261
Function	Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). In embryonic development is required for notochord formation. Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas and lungs; FOXA1 and FOXA2 seem to have at least in part redundant roles. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; regulates the expression of genes important for glucose sensing in pancreatic beta-cells and glucose homeostasis. Involved in regulation of fat metabolism. Binds to fibrinogen beta promoter and is involved in IL6-induced fibrinogen beta transcriptional activation.
Summary	This gene encodes a member of the forkhead class ofDNA-binding proteins. These hepatocyte nuclear factors aretranscriptional activators for liver-specific genes such as albuminand transthyretin, and they also interact with chromatin. Similarfamily members in mice have roles in the regulation of metabolismand in the differentiation of the pancreas and liver. This gene hasbeen linked to sporadic cases of maturity-onset diabetes of theyoung. Transcript variants encoding different isoforms have beenidentified for this gene.
Form	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Storage & Stability	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Applications	WB, IHC-P, IF, E
Dilution	WB~~1:1000 IHC-P~~1:10~50 IF~~1:10~50
Synonyms	Hepatocyte nuclear factor 3-beta, HNF-3-beta, HNF-3B, Forkhead box protein A2, Transcription factor 3B, TCF-3B, FOXA2, HNF3B, TCF3B
Images	FOXA2 Antibody (C-term) (Cat. AMM04588G) western blot analysis in MCF-7 cell line and rat stomach tissue lysates (35ug/lane).This demonstrates the FOXA2 antibody detected the FOXA2 protein (arrow). FOXA2 Antibody (C-term) (Cat. AMM04588G)immunohistochemistry analysis in formalin fixed and paraffin embedded human kidney tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of FOXA2 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated. Confocal immunofluorescent analysis of FOXA2 Antibody (C-term)( AMM04588G) with Hela cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). Actin filaments have been labeled with Alexa Fluor 555 phalloidin (red).DAPI was used to stain the cell nuclear (blue).
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