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SDR Antibody (Center)

Catalog # Availability Size / Price Inquiry
APR14399G 100 μl / $495

SDR Antibody (Center)

Brand

Leading Biology

Catalog Number

APR14399G

Product Type

Polyclonal Antibodies

Field of Research

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality SDR antibody (Center).

Molecular Weight

47173 Da

Cellular Localization

Antigen Cellular Localization: Cytoplasm, cytosol. Membrane, caveola. Note=Colocalizes with CAV1 to caveolae

Host

Rabbit

Species Reactivity

Human

Immunogen

109-135 aa

Target

This SDR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 109-135 amino acids from the Central region of human SDR.

Isotype

Rabbit Ig

GeneID

UniProt ID

Function

May play a role in targeting PRKCA to caveolae.

Summary

This gene encodes a calcium-independent phospholipid-binding protein whose expression increases in serum-starved cells. This protein is a substrate for protein kinase C (PKC) phosphorylation and recruits polymerase I and transcript release factor (PTRF) to caveolae. Removal of this protein causes caveolae loss and its over-expression results in caveolae deformation and membrane tubulation.

Form

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Applications

WB, IHC-P, FC, E

Dilution

WB~~1:1000 IHC-P~~1:50~100 FC~~1:10~50

Synonyms

Serum deprivation-response protein, Cavin-2, PS-p68, Phosphatidylserine-binding protein, SDPR {ECO:0000312|EMBL:AAD177951}

Images

Anti-SDR Antibody (Center) at 1:1000 dilution + human heart lysate Lysates/proteins at 20 μg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 47 kDa Blocking/Dilution buffer: 5% NFDM/TBST.

SDR Antibody (Center) (Cat. APR14399G) IHC analysis in formalin fixed and paraffin embedded lung carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the SDR Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.

SDR Antibody (Center) (Cat. APR14399G) flow cytometric analysis of NCI-H460 cells (bottom histogram) compared to a negative control cell (top histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.

Specification

Quantity

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