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HTATSF1 Antibody (N-term)

Catalog # Availability Size / Price Inquiry
AMM05389G 100 μl / $495

HTATSF1 Antibody (N-term)

Brand

Leading Biology

Catalog Number

AMM05389G

Product Type

Polyclonal Antibodies

Field of Research

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality HTATSF1 antibody (N-term).

Molecular Weight

85853 Da

Cellular Localization

Antigen Cellular Localization: Nucleus

Host

Rabbit

Species Reactivity

Human

Immunogen

1-30 aa

Target

This HTATSF1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human HTATSF1.

Isotype

Rabbit Ig

GeneID

UniProt ID

Function

Functions as a general transcription factor playing a role in the process of transcriptional elongation. May mediate the reciprocal stimulatory effect of splicing on transcriptional elongation. In case of infection by HIV-1, it is up-regulated by the HIV-1 proteins NEF and gp120, acts as a cofactor required for the Tat-enhanced transcription of the virus.

Summary

HTATSF1 functions as a cofactor for the stimulation of transcriptional elongation by HIV-1 Tat, which binds to the HIV-1 promoter through Tat-TAR interaction. This protein may also serve as a dual-function factor to couple transcription and splicing and to facilitate their reciprocal activation.

Form

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Applications

WB, IHC-P, E

Dilution

WB~~1:1000 IHC-P~~1:50~100

Synonyms

HIV Tat-specific factor 1, Tat-SF1, HTATSF1

Images

Western blot analysis of HTATSF1 Antibody (N-term) (Cat. AMM05389G) in Jurkat cell line lysates (35ug/lane). HTATSF1 (arrow) was detected using the purified Pab.

Formalin-fixed and paraffin-embedded human brain tissue with HTATSF1 Antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

Specification

Quantity

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