> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > RRM2B Antibody (Center)Brand |
Leading Biology | Catalog Number |
AMR09782G |
Product Type |
Polyclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality RRM2B antibody (Center).
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Molecular Weight |
40737 Da
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Cellular Localization |
Antigen Cellular Localization:
Cytoplasm. Nucleus. Note=Translocates from cytoplasm to nucleus in response to DNA damage
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Host |
Rabbit
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Species Reactivity |
Human
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Immunogen |
128-157 aa
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Target |
This RRM2B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 128-157 amino acids from the Central region of human RRM2B.
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Isotype |
Rabbit Ig
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Symbol |
P53R2
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GeneID |
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UniProt ID |
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Function |
Plays a pivotal role in cell survival by repairing damaged DNA in a p53/TP53-dependent manner. Supplies deoxyribonucleotides for DNA repair in cells arrested at G1 or G2. Contains an iron-tyrosyl free radical center required for catalysis. Forms an active ribonucleotide reductase (RNR) complex with RRM1 which is expressed both in resting and proliferating cells in response to DNA damage.
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Summary |
This gene encodes the small subunit of a p53-inducibleribonucleotide reductase. This heterotetrameric enzyme catalyzesthe conversion of ribonucleoside diphosphates todeoxyribonucleoside diphosphates. The product of this reaction isnecessary for DNA synthesis. Mutations in this gene have beenassociated with autosomal recessive mitochondrial DNA depletionsyndrome, autosomal dominant progressive externalophthalmoplegia-5, and mitochondrial neurogastrointestinalencephalopathy. Alternatively spliced transcript variants have beendescribed.
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Form |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, E
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Dilution |
WB~~1:1000
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Synonyms |
Ribonucleoside-diphosphate reductase subunit M2 B, TP53-inducible ribonucleotide reductase M2 B, p53-inducible ribonucleotide reductase small subunit 2-like protein, p53R2, RRM2B, P53R2
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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