> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > TPP1 Antibody (N-term)Brand |
Leading Biology | Catalog Number |
APR13781G |
Product Type |
Polyclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality TPP1 antibody (N-term).
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Molecular Weight |
61248 Da
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Cellular Localization |
Antigen Cellular Localization:
Lysosome. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV
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Host |
Rabbit
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Species Reactivity |
Human
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Immunogen |
6-34 aa
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Target |
This TPP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 6-34 amino acids from the N-terminal region of human TPP1.
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Isotype |
Rabbit Ig
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Symbol |
CLN2
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GeneID |
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UniProt ID |
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Function |
Lysosomal serine protease with tripeptidyl-peptidase I activity. May act as a non-specific lysosomal peptidase which generates tripeptides from the breakdown products produced by lysosomal proteinases. Requires substrates with an unsubstituted N-terminus (By similarity).
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Summary |
This gene encodes a member of the sedolisin family ofserine proteases. The protease functions in the lysosome to cleaveN-terminal tripeptides from substrates, and has weakerendopeptidase activity. It is synthesized as acatalytically-inactive enzyme which is activated andauto-proteolyzed upon acidification. Mutations in this gene resultin late-infantile neuronal ceroid lipofuscinosis, which isassociated with the failure to degrade specific neuropeptides and asubunit of ATP synthase in the lysosome.
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Form |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, E
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Dilution |
WB~~1:1000
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Synonyms |
Tripeptidyl-peptidase 1, TPP-1, Cell growth-inhibiting gene 1 protein, Lysosomal pepstatin-insensitive protease, LPIC, Tripeptidyl aminopeptidase, Tripeptidyl-peptidase I, TPP-I, TPP1, CLN2
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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