> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > ZIC1 Antibody (N-term)Brand |
Leading Biology | Catalog Number |
APR14033G |
Product Type |
Polyclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality ZIC1 antibody (N-term).
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Molecular Weight |
48309 Da
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Cellular Localization |
Antigen Cellular Localization:
Nucleus. Cytoplasm. Note=Localizes in the cytoplasm in presence of MDFIC overexpression.
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Host |
Rabbit
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Species Reactivity |
Human
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Immunogen |
6-34 aa
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Target |
This ZIC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 6-34 amino acids from the N-terminal region of human ZIC1.
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Isotype |
Rabbit Ig
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Symbol |
ZIC, ZNF201
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GeneID |
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UniProt ID |
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Function |
Acts as a transcriptional activator. Involved in neurogenesis. Plays important roles in the early stage of organogenesis of the CNS, as well as during dorsal spinal cord development and maturation of the cerebellum. Involved in the spatial distribution of mossy fiber (MF) neurons within the pontine gray nucleus (PGN). Plays a role in the regulation of MF axon pathway choice. Promotes MF migration towards ipsilaterally- located cerebellar territories. May have a role in shear flow mechanotransduction in osteocytes. Retains nuclear GLI1 and GLI3 in the cytoplasm. Binds to the minimal GLI-consensus sequence 5'- TGGGTGGTC-3' (By similarity).
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Summary |
This gene encodes a member of the ZIC family of C2H2-typezinc finger proteins. Members of this family are important duringdevelopment. Aberrant expression of this gene is seen inmedulloblastoma, a childhood brain tumor. This gene is closelylinked to the gene encoding zinc finger protein of the cerebellum4, a related family member on chromosome 3. This gene encodes atranscription factor that can bind and transactivate theapolipoprotein E gene.
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Form |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, E
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Dilution |
WB~~1:1000
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Synonyms |
Zinc finger protein ZIC 1, Zinc finger protein 201, Zinc finger protein of the cerebellum 1, ZIC1, ZIC, ZNF201
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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