> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > ACVR1 Antibody (Center)Brand |
Leading Biology | Catalog Number |
APR14809G |
Product Type |
Polyclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality ACVR1 antibody (Center).
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Molecular Weight |
57153 Da
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Cellular Localization |
Antigen Cellular Localization:
Membrane; Single-pass type I membrane protein
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Host |
Rabbit
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Species Reactivity |
Human
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Immunogen |
132-161 aa
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Target |
This ACVR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 132-161 amino acids from the Central region of human ACVR1.
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Isotype |
Rabbit Ig
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Symbol |
ACVRLK2
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GeneID |
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UniProt ID |
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Function |
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin. May be involved for left-right pattern formation during embryogenesis (By similarity).
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Summary |
Activins are dimeric growth and differentiation factorswhich belong to the transforming growth factor-beta (TGF-beta)superfamily of structurally related signaling proteins. Activinssignal through a heteromeric complex of receptor serine kinaseswhich include at least two type I ( I and IB) and two type II (IIand IIB) receptors. These receptors are all transmembrane proteins,composed of a ligand-binding extracellular domain withcysteine-rich region, a transmembrane domain, and a cytoplasmicdomain with predicted serine/threonine specificity. Type Ireceptors are essential for signaling; and type II receptors arerequired for binding ligands and for expression of type Ireceptors. Type I and II receptors form a stable complex afterligand binding, resulting in phosphorylation of type I receptors bytype II receptors. This gene encodes activin A type I receptorwhich signals a particular transcriptional response in concert withactivin type II receptors. Mutations in this gene are associatedwith fibrodysplasia ossificans progressive.
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Form |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, E
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Dilution |
WB~~1:1000
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Synonyms |
Activin receptor type-1, Activin receptor type I, ACTR-I, Activin receptor-like kinase 2, ALK-2, Serine/threonine-protein kinase receptor R1, SKR1, TGF-B superfamily receptor type I, TSR-I, ACVR1, ACVRLK2
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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