> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > POFUT2 Antibody (Center)Brand |
Leading Biology | Catalog Number |
AMR09418G |
Product Type |
Polyclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality POFUT2 antibody (Center).
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Molecular Weight |
49976 Da
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Cellular Localization |
Antigen Cellular Localization:
Endoplasmic reticulum. Golgi apparatus. Note=Mainly located in the endoplasmic reticulum
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Host |
Rabbit
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Species Reactivity |
Human
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Immunogen |
228-257 aa
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Target |
This POFUT2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 228-257 amino acids from the Central region of human POFUT2.
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Isotype |
Rabbit Ig
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Symbol |
C21orf80, FUT13, KIAA0958
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GeneID |
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UniProt ID |
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Function |
Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue in the consensus sequence C1-X(2,3)-S/T-C2-X(2)-G of thrombospondin type 1 repeats where C1 and C2 are the first and second cysteines, respectively. O-fucosylates members of several protein families including the ADAMTS family, the thrombosporin (TSP) and spondin families. The O-fucosylation of TSRs is also required for restricting epithelial to mesenchymal transition (EMT), maintaining the correct patterning of mesoderm and localization of the definite endoderm (By similarity). Required for the proper secretion of ADAMTS family members such as ADAMSL1 and ADAMST13.
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Summary |
Fucose is typically found as a terminal modification ofbranched chain glycoconjugates, but it also exists in directO-linkage to serine or threonine residues within cystine knotmotifs in epidermal growth factor (EGF; MIM 131530)-like repeats orthrombospondin (THBS; see MIM 188060) type-1 repeats. POFUT2 is anO-fucosyltransferase that use THBS type-1 repeats as substrates(Luo et al., 2006 [PubMed 16464857]).
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Form |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, IHC-P, E
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Dilution |
WB~~1:1000
IHC-P~~1:10~50
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Synonyms |
GDP-fucose protein O-fucosyltransferase 2, Peptide-O-fucosyltransferase 2, O-FucT-2, POFUT2, C21orf80, FUT13, KIAA0958
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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