> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > FCN3 Antibody (C-term)Brand |
Leading Biology | Catalog Number |
APR15944G |
Product Type |
Polyclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality FCN3 antibody (C-term).
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Molecular Weight |
32903 Da
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Cellular Localization |
Antigen Cellular Localization:
Secreted. Note=Found in blood plasma, bronchus, alveolus and bile duct
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Host |
Rabbit
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Species Reactivity |
Human
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Immunogen |
214-243 aa
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Target |
This FCN3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 214-243 amino acids from the C-terminal region of human FCN3.
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Isotype |
Rabbit Ig
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Symbol |
FCNH, HAKA1
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GeneID |
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UniProt ID |
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Function |
May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent and GlcNAc- binding lectin. Has affinity with GalNAc, GlcNAc, D-fucose, as mono/oligosaccharide and lipopolysaccharides from S.typhimurium and S.minnesota.
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Summary |
Ficolins are a group of proteins which consist of acollagen-like domain and a fibrinogen-like domain. In human serum,there are two types of ficolins, both of which have lectinactivity. The protein encoded by this gene is a thermolabilebeta-2-macroglycoprotein found in all human serum and is a memberof the ficolin/opsonin p35 lectin family. The protein, which wasinitially identified based on its reactivity with sera frompatients with systemic lupus erythematosus, has been shown to havea calcium-independent lectin activity. The protein can activate thecomplement pathway in association with MASPs and sMAP, therebyaiding in host defense through the activation of the lectinpathway. Alternative splicing occurs at this locus and twovariants, each encoding a distinct isoform, have been identified.
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Form |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, IHC-P, FC, E
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Dilution |
WB~~1:1000
IHC-P~~1:10~50
FC~~1:10~50
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Synonyms |
Ficolin-3, Collagen/fibrinogen domain-containing lectin 3 p35, Collagen/fibrinogen domain-containing protein 3, Hakata antigen, FCN3, FCNH, HAKA1
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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