> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > VEGFA Antibody (Center)Brand |
Leading Biology | Catalog Number |
APR10718G |
Product Type |
Polyclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality VEGFA antibody (Center).
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Molecular Weight |
27042 Da
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Cellular Localization |
Antigen Cellular Localization:
Secreted Note=VEGF121 is acidic and freely secreted. VEGF165 is more basic, has heparin-binding properties and, although a signicant proportion remains cell-associated, most is freely secreted VEGF189 is very basic, it is cell-associated after secretion and is bound avidly by heparin and the extracellular matrix, although it may be released as a soluble form by heparin, heparinase or plasmin
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Host |
Rabbit
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Species Reactivity |
Human
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Immunogen |
140-168 aa
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Target |
This VEGFA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 140-168 amino acids from the Central region of human VEGFA.
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Isotype |
Rabbit Ig
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Symbol |
VEGF
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GeneID |
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UniProt ID |
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Function |
Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. NRP1/Neuropilin-1 binds isoforms VEGF-165 and VEGF-145. Isoform VEGF165B binds to KDR but does not activate downstream signaling pathways, does not activate angiogenesis and inhibits tumor growth.
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Summary |
This gene is a member of the PDGF/VEGF growth factorfamily and encodes a protein that is often found as a disulfidelinked homodimer. This protein is a glycosylated mitogen thatspecifically acts on endothelial cells and has various effects,including mediating increased vascular permeability, inducingangiogenesis, vasculogenesis and endothelial cell growth, promotingcell migration, and inhibiting apoptosis. Elevated levels of thisprotein is linked to POEMS syndrome, also known as Crow-Fukasesyndrome. Mutations in this gene have been associated withproliferative and nonproliferative diabetic retinopathy.Alternatively spliced transcript variants, encoding either freelysecreted or cell-associated isoforms, have been characterized.There is also evidence for the use of non-AUG (CUG) translationinitiation sites upstream of, and in-frame with the first AUG,leading to additional isoforms.
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Form |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, E
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Dilution |
WB~~1:1000
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Synonyms |
Vascular endothelial growth factor A, VEGF-A, Vascular permeability factor, VPF, VEGFA, VEGF
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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