> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > P2X3 Receptor AntibodyBrand |
Leading Biology | Catalog Number |
APR00514G |
Product Type |
Polyclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality P2X3 Receptor Antibody.
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Molecular Weight |
44392 Da
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Host |
Rabbit
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Species Reactivity |
Human, Mouse, Rat
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Target |
Peptide (C)VEKQSTDSGAYSIGH, corresponding to amino acid residues 383-397 of rat P2X3 Receptor??(Accession P49654).????Intracellular, C-terminus.
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GeneID |
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UniProt ID |
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Summary |
The P2X3 receptorbelongs to the ligand-gated ion channel P2X family, that consists of seven receptor subtypes named P2X1-P2X7 and is activated by extracellular ATP.1,2,3All P2X subunits, with the exception of P2X6, can assemble to form homomeric or heteromeric functional channels.4-5The different P2X receptors show distinct expression patterns. P2X1-6 has been found in thecentral and peripheral nervous system, while the P2X7 receptor is predominantly found in cells of the immune system. The P2X3 receptor is highly expressed on nociceptive sensory neurons in dorsal root ganglia (DRG) as a homomer or as a heteromer (P2X3/P2X2). ATP released from damaged cells activates the P2X3 receptor to initiate nociceptive signals.6,7Involvement of ATP in the mechanism of chronic pain has been also suggested.7,8P2X3 receptor is now becoming a possible target for the development of pain therapeutics.
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Form |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB
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Dilution |
WB~~1:200-1:2000
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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