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TROP2 Antibody (Center)

Catalog # Availability Size / Price Inquiry
APR05782G 100 μl / $495

TROP2 Antibody (Center)

Brand

Leading Biology

Catalog Number

APR05782G

Product Type

Polyclonal Antibodies

Field of Research

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality TROP2 Antibody (Center).

Molecular Weight

35709 Da

Cellular Localization

Antigen Cellular Localization: Membrane; Single-pass type I membrane protein

Host

Rabbit

Species Reactivity

Human

Immunogen

162-190 aa

Target

This TROP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 162-190 amino acids from the Central region of human TROP2.

Isotype

Rabbit Ig

Symbol

GA733-1, M1S1, TROP2

GeneID

UniProt ID

Function

May function as a growth factor receptor.

Summary

TROP2 is a carcinoma-associated antigen defined by the monoclonal antibody GA733. This antigen is a member of a family including at least two type I membrane proteins. It transduces an intracellular calcium signal and acts as a cell surface receptor. Mutations of its gene result in gelatinous drop-like corneal dystrophy, an autosomal recessive disorder characterized by severe corneal amyloidosis leading to blindness.

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Applications

WB, IHC-P, E

Dilution

WB~~1:1000 IHC-P~~1:50~100

Images

Western blot analysis of TROP2 antibody (Center) (Cat. APR05782G) in HL60 cell line lysates (35ug/lane). TROP2 (arrow) was detected using the purified Pab.

Formalin-fixed and paraffin-embedded human prostate carcinoma with TROP2 Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

Specification

Quantity

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