> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > SH2D1A Antibody (C-term)Brand |
Leading Biology | Catalog Number |
APR04500G |
Product Type |
Polyclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality SH2D1A Antibody (C-term).
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Molecular Weight |
14187 Da
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Cellular Localization |
Antigen Cellular Localization:
Cytoplasm.
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Host |
Rabbit
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Species Reactivity |
Human
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Immunogen |
85-114 aa
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Target |
This SH2D1A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 85-114 amino acids from the C-terminal region of human SH2D1A.
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Isotype |
Rabbit Ig
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Symbol |
DSHP, SAP
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GeneID |
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UniProt ID |
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Function |
Inhibitor of the SLAM self-association. Acts by blocking recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to a docking site in the SLAM cytoplasmic region. Mediates interaction between FYN and SLAMF1. May also regulate the activity of the neurotrophin receptors NTRK1, NTRK2 and NTRK3.
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Summary |
This gene encodes a protein that plays a major role in thebidirectional stimulation of T and B cells. This protein containsan SH2 domain and a short tail. It associates with the signalinglymphocyte-activation molecule, thereby acting as an inhibitor ofthis transmembrane protein by blocking the recruitment of theSH2-domain-containing signal-transduction molecule SHP-2 to itsdocking site. This protein can also bind to other related surfacemolecules that are expressed on activated T, B and NK cells,thereby modifying signal transduction pathways in these cells.Mutations in this gene cause lymphoproliferative syndrome X-linkedtype 1 or Duncan disease, a rare immunodeficiency characterized byextreme susceptibility to infection with Epstein-Barr virus, withsymptoms including severe mononucleosis and malignant lymphoma.Multiple transcript variants encoding different isoforms have beenfound for this gene.
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, E
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Dilution |
WB~~1:1000
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Images |
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Specification |
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Quantity |
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| 4 | Leading Biology | APR03844G | UBE2W Antibody (C-term) | 100 μl | Polyclonal Antibodies |
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| 5 | Leading Biology | APR04349G | HECTD2 Antibody (N-term) | 100 μl | Polyclonal Antibodies |
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| 6 | Leading Biology | APR03502G | IGHG1 Antibody (Center) | 100 μl | Polyclonal Antibodies |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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