> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > PPM1F Antibody (Center)Brand |
Leading Biology | Catalog Number |
APR04499G |
Product Type |
Polyclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality PPM1F Antibody (Center).
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Molecular Weight |
49831 Da
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Host |
Rabbit
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Species Reactivity |
Human
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Immunogen |
275-303 aa
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Target |
This PPM1F antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 275-303 amino acids from the Central region of human PPM1F.
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Isotype |
Rabbit Ig
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Symbol |
KIAA0015, POPX2
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GeneID |
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UniProt ID |
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Function |
Dephosphorylates and concomitantly deactivates CaM- kinase II activated upon autophosphorylation, and CaM-kinases IV and I activated upon phosphorylation by CaM-kinase kinase. Promotes apoptosis.
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Summary |
The protein encoded by this gene is a member of the PP2Cfamily of Ser/Thr protein phosphatases. PP2C family members areknown to be negative regulators of cell stress response pathways.This phosphatase can interact with Rho guanine nucleotide exchangefactors (PIX), and thus block the effects of p21-activated kinase 1(PAK), a protein kinase mediating biological effects downstream ofRho GTPases. Calcium/calmodulin-dependent protein kinase II gamma(CAMK2G/CAMK-II) is found to be one of the substrates of thisphosphatase. The overexpression of this phosphatase or CAMK2G hasbeen shown to mediate caspase-dependent apoptosis. An alternativelyspliced transcript variant has been identified, but its full-lengthnature has not been determined.
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, E
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Dilution |
WB~~1:1000
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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