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FIGLA Antibody (Center)

Catalog # Availability Size / Price Inquiry
APR04274G 100 μl / $495

FIGLA Antibody (Center)

Brand

Leading Biology

Catalog Number

APR04274G

Product Type

Polyclonal Antibodies

Field of Research

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality FIGLA Antibody (Center).

Molecular Weight

24123 Da

Cellular Localization

Antigen Cellular Localization: Nucleus.

Host

Rabbit

Species Reactivity

Human

Immunogen

108-137 aa

Target

This FIGLA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 108-137 amino acids from the Central region of human FIGLA.

Isotype

Rabbit Ig

Symbol

BHLHC8

GeneID

UniProt ID

Function

Germline specific transcription factor implicated in postnatal oocyte-specific gene expression. Plays a key regulatory role in the expression of multiple oocyte-specific genes, including those that initiate folliculogenesis and those that encode the zona pellucida (ZP1, ZP2 and ZP3) required for fertilization and early embryonic survival. Essential for oocytes to survive and form primordial follicles. The persistence of FIGLA in adult females suggests that it may regulate additional pathways that are essential for normal ovarian development. Binds to the E- box (5'-CANNTG-3') of the ZPs (ZP1, ZP2, ZP3) promoters.

Summary

This gene encodes a protein that functions in postnataloocyte-specific gene expression. The protein is a basichelix-loop-helix transcription factor that regulates multipleoocyte-specific genes, including genes involved in folliculogenesisand those that encode the zona pellucida. Mutations in this genecause premature ovarian failure type 6.

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Applications

WB, E

Dilution

WB~~1:1000

Images

All lanes : Anti-FIGLA Antibody (Center) at 1:1000 dilution Lane 1: human ovary lysate Lane 2: T47D whole cell lysate Lysates/proteins at 20 μg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 24 kDa Blocking/Dilution buffer: 5% NFDM/TBST.

Specification

Quantity

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