> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > FBLN5 Antibody (C-term)Brand |
Leading Biology | Catalog Number |
APR04273G |
Product Type |
Polyclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality FBLN5 Antibody (C-term).
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Molecular Weight |
50180 Da
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Cellular Localization |
Antigen Cellular Localization:
Secreted Secreted, extracellular space, extracellular matrix. Note=co-localizes with ELN in elastic fibers.
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Host |
Rabbit
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Species Reactivity |
Human
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Immunogen |
393-421 aa
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Target |
This FBLN5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 393-421 amino acids from the C-terminal region of human FBLN5.
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Isotype |
Rabbit Ig
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Symbol |
DANCE
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GeneID |
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UniProt ID |
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Function |
Essential for elastic fiber formation, is involved in the assembly of continuous elastin (ELN) polymer and promotes the interaction of microfibrils and ELN (PubMed:18185537). Stabilizes and organizes elastic fibers in the skin, lung and vasculature (By similarity). Promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. Vascular ligand for integrin receptors which may play a role in vascular development and remodeling (PubMed:10428823).
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Summary |
The protein encoded by this gene is a secreted,extracellular matrix protein containing an Arg-Gly-Asp (RGD) motifand calcium-binding EGF-like domains. It promotes adhesion ofendothelial cells through interaction of integrins and the RGDmotif. It is prominently expressed in developing arteries but lessso in adult vessels. However, its expression is reinduced inballoon-injured vessels and atherosclerotic lesions, notably inintimal vascular smooth muscle cells and endothelial cells.Therefore, the protein encoded by this gene may play a role invascular development and remodeling. Defects in this gene are acause of autosomal dominant cutis laxa, autosomal recessive cutislaxa type I (CL type I), and age-related macular degeneration type3 (ARMD3).
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, E
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Dilution |
WB~~1:1000
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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