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CSTA Antibody (C-term)

Catalog # Availability Size / Price Inquiry
APR03951G 100 μl / $495

CSTA Antibody (C-term)

Brand

Leading Biology

Catalog Number

APR03951G

Product Type

Polyclonal Antibodies

Field of Research

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality CSTA Antibody (C-term).

Molecular Weight

11006 Da

Cellular Localization

Antigen Cellular Localization: Cytoplasm.

Host

Rabbit

Species Reactivity

Human

Immunogen

69-98 aa

Target

This CSTA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 69-98 amino acids from the C-terminal region of human CSTA.

Isotype

Rabbit Ig

Symbol

STF1, STFA

GeneID

UniProt ID

Function

This is an intracellular thiol proteinase inhibitor. Has an important role in desmosome-mediated cell-cell adhesion in the lower levels of the epidermis.

Summary

The cystatin superfamily encompasses proteins that containmultiple cystatin-like sequences. Some of the members are activecysteine protease inhibitors, while others have lost or perhapsnever acquired this inhibitory activity. There are three inhibitoryfamilies in the superfamily, including the type 1 cystatins(stefins), type 2 cystatins, and kininogens. This gene encodes astefin that functions as a cysteine protease inhibitor, formingtight complexes with papain and the cathepsins B, H, and L. Theprotein is one of the precursor proteins of cornified cell envelopein keratinocytes and plays a role in epidermal development andmaintenance. Stefins have been proposed as prognostic anddiagnostic tools for cancer.

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Applications

WB, IHC-P, E

Dilution

WB~~1:1000 IHC-P~~1:10~50

Images

CSTA Antibody (C-term) (Cat. APR03951G) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the CSTA antibody detected the CSTA protein (arrow).

Western blot analysis of CSTA (arrow) using rabbit polyclonal CSTA Antibody (C-term) (Cat. APR03951G). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the CSTA gene.

CSTA Antibody (C-term) (APR03951G)immunohistochemistry analysis in formalin fixed and paraffin embedded human skin tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of CSTA Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.

Specification

Quantity

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