> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > PTPRC Antibody (N-term)Brand |
Leading Biology | Catalog Number |
APR03605G |
Product Type |
Polyclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality PTPRC Antibody (N-term).
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Molecular Weight |
147254 Da
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Cellular Localization |
Antigen Cellular Localization:
Membrane; Single-pass type I membrane protein Membrane raft. Note=Colocalized with DPP4 in membrane rafts
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Host |
Rabbit
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Species Reactivity |
Human
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Immunogen |
336-364 aa
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Target |
This PTPRC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 336-364 amino acids from the N-terminal region of human PTPRC.
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Isotype |
Rabbit Ig
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Symbol |
CD45
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GeneID |
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UniProt ID |
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Function |
Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity (By similarity).
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Summary |
The protein encoded by this gene is a member of theprotein tyrosine phosphatase (PTP) family. PTPs are known to besignaling molecules that regulate a variety of cellular processesincluding cell growth, differentiation, mitotic cycle, andoncogenic transformation. This PTP contains an extracellulardomain, a single transmembrane segment and two tandemintracytoplasmic catalytic domains, and thus belongs to receptortype PTP. This gene is specifically expressed in hematopoieticcells. This PTP has been shown to be an essential regulator of T-and B-cell antigen receptor signaling. It functions through eitherdirect interaction with components of the antigen receptorcomplexes, or by activating various Src family kinases required forthe antigen receptor signaling. This PTP also suppresses JAKkinases, and thus functions as a regulator of cytokine receptorsignaling. Four alternatively spliced transcripts variants of thisgene, which encode distinct isoforms, have been reported. [providedby RefSeq].
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, FC, E
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Dilution |
WB~~1:1000
FC~~1:10~50
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Images |
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Specification |
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Quantity |
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| 6 | Leading Biology | APR03502G | IGHG1 Antibody (Center) | 100 μl | Polyclonal Antibodies |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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