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TLR3 Polyclonal Antibody

Catalog # Availability Size / Price Inquiry
APR18641N-1 50ul / $395
APR18641N-2 100ul / $495
APR18641N-3 200ul / $595

TLR3 Polyclonal Antibody

Brand

Leading Biology

Catalog Number

APR18641N

Product Type

Polyclonal Antibodies

Field of Research

Immunology & Inflammation>CDs

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality TLR3 Polyclonal Antibody.

Molecular Weight

Calculated MW: 72kDa/103kDa Observed MW: 120kDa

Species Reactivity

Rabbit

Immunogen

Recombinant fusion protein of human TLR3 (NP_003256.1).

Cross Reactivity

Human

Isotype

IgG

GeneID

UniProt ID

Purity

Affinity purification

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Storage Buffer

Buffer: PBS with 50% glycerol, pH7.3.

Applications

WB

Dilution

WB 1:500 - 1:2000

Product Description

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta and pancreas, and is restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection, and induces the activation of NF-kappaB and the production of type I interferons. It may thus play a role in host defense against viruses. Use of alternative polyadenylation sites to generate different length transcripts has been noted for this gene.

Synonyms

TLR3; CD283; IIAE2; toll-like receptor 3

Images

Western blot analysis of extracts of various cell lines, using TLR3 antibody.

Western blot analysis of extracts of various cell lines, using TLR3 antibody.

Specification

Quantity

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