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SDHB Polyclonal Antibody

Catalog # Availability Size / Price Inquiry
APR18288N-1 50ul / $395
APR18288N-2 100ul / $495
APR18288N-3 200ul / $595

SDHB Polyclonal Antibody

Brand

Leading Biology

Catalog Number

APR18288N

Product Type

Polyclonal Antibodies

Field of Research

Endocrine & Metabolism>Mitochondrial metabolism

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality SDHB Polyclonal Antibody.

Molecular Weight

Calculated MW: 31kDa Observed MW: 32kDa

Species Reactivity

Rabbit

Immunogen

Recombinant fusion protein of human SDHB (NP_002991.2).

Cross Reactivity

Human,Mouse,Rat

Isotype

IgG

GeneID

UniProt ID

Purity

Affinity purification

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Storage Buffer

Buffer: PBS with 50% glycerol, pH7.3.

Applications

WB,IHC

Dilution

WB 1:500 - 1:2000 IHC 1:50 - 1:100

Product Description

Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. The iron-sulfur subunit is highly conserved and contains three cysteine-rich clusters which may comprise the iron-sulfur centers of the enzyme. Sporadic and familial mutations in this gene result in paragangliomas and pheochromocytoma, and support a link between mitochondrial dysfunction and tumorigenesis.

Synonyms

SDHB; CWS2; IP; PGL4; SDH; SDH1; SDH2; SDHIP; succinate dehydrogenase complex iron sulfur subunit B

Images

Western blot analysis of extracts of various cell lines, using SDHB antibody.

Immunohistochemistry of paraffin-embedded human colon using SDHB antibody.

Immunohistochemistry of paraffin-embedded human lung cancer using SDHB antibody.

Specification

Quantity

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