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PHOX2B Polyclonal Antibody

Catalog # Availability Size / Price Inquiry
APR28644N-1 50ul / $395
APR28644N-2 100ul / $495
APR28644N-3 200ul / $595

PHOX2B Polyclonal Antibody

Brand

Leading Biology

Catalog Number

APR28644N

Product Type

Polyclonal Antibodies

Field of Research

Epigenetics & Nuclear Signaling>Transcription Factors

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality PHOX2B Polyclonal Antibody.

Molecular Weight

Calculated MW: 31kDa Observed MW: 32kDa

Species Reactivity

Rabbit

Immunogen

Recombinant fusion protein of human PHOX2B (NP_003915.2).

Cross Reactivity

Human,Mouse,Rat

Isotype

IgG

GeneID

UniProt ID

Purity

Affinity purification

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Storage Buffer

Buffer: PBS with 50% glycerol, pH7.3.

Applications

WB,IHC

Dilution

WB 1:500 - 1:2000 IHC 1:50 - 1:200

Product Description

The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins localized to the nucleus. The protein functions as a transcription factor involved in the development of several major noradrenergic neuron populations and the determination of neurotransmitter phenotype. The gene product is linked to enhancement of second messenger-mediated activation of the dopamine beta-hydroylase, c-fos promoters and several enhancers, including cyclic amp-response element and serum-response element. Expansion of a 20 amino acid polyalanine tract in this protein by 5-13 aa has been associated with congenital central hypoventilation syndrome.

Synonyms

PHOX2B; NBLST2; NBPhox; PMX2B; paired like homeobox 2b

Images

Western blot analysis of extracts of various cell lines, using PHOX2B antibody.

Immunohistochemistry of paraffin-embedded rat liver using PHOX2B antibody.

Immunohistochemistry of paraffin-embedded rat kidney using PHOX2B antibody.

Specification

Quantity

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