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CSE1L Polyclonal Antibody

Catalog # Availability Size / Price Inquiry
APR28613N-1 50ul / $395
APR28613N-2 100ul / $495
APR28613N-3 200ul / $595

CSE1L Polyclonal Antibody

Brand

Leading Biology

Catalog Number

APR28613N

Product Type

Polyclonal Antibodies

Field of Research

Cell Biology & Developmental Biology>Apoptosis

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality CSE1L Polyclonal Antibody.

Molecular Weight

Calculated MW: 22kDa/103kDa/107kDa/110kDa Observed MW: 110kDa

Species Reactivity

Rabbit

Immunogen

A synthetic peptide of human CSE1L (NP_001243064.1).

Cross Reactivity

Human,Rat

Isotype

IgG

GeneID

UniProt ID

Purity

Affinity purification

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Storage Buffer

Buffer: PBS with 50% glycerol, pH7.3.

Applications

WB,IHC

Dilution

WB 1:500 - 1:2000 IHC 1:100 - 1:200

Product Description

Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer. Importin-alpha binds the NLS, while importin-beta mediates translocation through the nuclear pore complex. After translocation, RanGTP binds importin-beta and displaces importin-alpha. Importin-alpha must then be returned to the cytoplasm, leaving the NLS protein behind. The protein encoded by this gene binds strongly to NLS-free importin-alpha, and this binding is released in the cytoplasm by the combined action of RANBP1 and RANGAP1. In addition, the encoded protein may play a role both in apoptosis and in cell proliferation. Alternatively spliced transcript variants have been found for this gene.

Synonyms

CSE1L; CAS; CSE1; XPO2; exportin-2

Images

Western blot analysis of extracts of various cell lines, using CSE1L antibody.

Specification

Quantity

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