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FGD4 Polyclonal Antibody

Catalog # Availability Size / Price Inquiry
APR28373N-1 50ul / $395
APR28373N-2 100ul / $495
APR28373N-3 200ul / $595

FGD4 Polyclonal Antibody

Brand

Leading Biology

Catalog Number

APR28373N

Product Type

Polyclonal Antibodies

Field of Research

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality FGD4 Polyclonal Antibody.

Molecular Weight

Calculated MW: 20kDa/32kDa/86kDa Observed MW: 100kDa

Species Reactivity

Rabbit

Immunogen

Recombinant fusion protein of human FGD4 (NP_640334.2).

Cross Reactivity

Human,Mouse,Rat

Isotype

IgG

GeneID

UniProt ID

Purity

Affinity purification

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Storage Buffer

Buffer: PBS with 50% glycerol, pH7.3.

Applications

WB

Dilution

WB 1:500 - 1:2000

Product Description

This gene encodes a protein that is involved in the regulation of the actin cytoskeleton and cell shape. This protein contains an actin filament-binding domain, which together with its Dbl homology domain and one of its pleckstrin homology domains, can form microspikes. This protein can activate MAPK8 independently of the actin filament-binding domain, and it is also involved in the activation of CDC42 via the exchange of bound GDP for free GTP. The activation of CDC42 also enables this protein to play a role in mediating the cellular invasion of Cryptosporidium parvum, an intracellular parasite that infects the gastrointestinal tract. Mutations in this gene can cause Charcot-Marie-Tooth disease type 4H (CMT4H), a disorder of the peripheral nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Synonyms

FGD4; CMT4H; FRABP; ZFYVE6; FYVE, RhoGEF and PH domain containing 4

Images

Western blot analysis of extracts of various cell lines, using FGD4 antibody.

Specification

Quantity

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