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Location: Home > Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > [KO Validated] XIAP Polyclonal Antibody

[KO Validated] XIAP Polyclonal Antibody

Catalog # Availability Size / Price Inquiry
APR26891N-1 50ul / $395
APR26891N-2 100ul / $495
APR26891N-3 200ul / $595

[KO Validated] XIAP Polyclonal Antibody

Brand

Leading Biology

Catalog Number

APR26891N

Product Type

Polyclonal Antibodies

Field of Research

Cell Biology & Developmental Biology>Apoptosis

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality [KO Validated] XIAP Polyclonal Antibody.

Molecular Weight

Calculated MW: 56kDa Observed MW: 54kDa

Species Reactivity

Rabbit

Immunogen

Recombinant fusion protein of human XIAP (NP_001158.2).

Cross Reactivity

Human,Mouse,Rat

Isotype

IgG

GeneID

UniProt ID

Purity

Affinity purification

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Storage Buffer

Buffer: PBS with 50% glycerol, pH7.3.

Applications

WB,IHC,IF

Dilution

WB 1:500 - 1:2000 IHC 1:50 - 1:100 IF 1:50 - 1:100

Product Description

This gene encodes a protein that belongs to a family of apoptotic suppressor proteins. Members of this family share a conserved motif termed, baculovirus IAP repeat, which is necessary for their anti-apoptotic function. This protein functions through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 and inhibits apoptosis induced by menadione, a potent inducer of free radicals, and interleukin 1-beta converting enzyme. This protein also inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7. Mutations in this gene are the cause of X-linked lymphoproliferative syndrome. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 2 and 11.

Synonyms

XIAP; API3; BIRC4; IAP-3; ILP1; MIHA; XLP2; hIAP-3; hIAP3; X-linked inhibitor of apoptosis

Images

Western blot analysis of extracts of various cell lines, using XIAP antibody.

Western blot analysis of extracts from normal (control) and XIAP knockout (KO) HeLa cells, using XIAP antibody.

Immunohistochemistry of paraffin-embedded human kidney using XIAP antibody.

Specification

Quantity

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