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MUS81 Polyclonal Antibody

Catalog # Availability Size / Price Inquiry
APR26866N-1 50ul / $395
APR26866N-2 100ul / $495
APR26866N-3 200ul / $595

MUS81 Polyclonal Antibody

Brand

Leading Biology

Catalog Number

APR26866N

Product Type

Polyclonal Antibodies

Field of Research

Epigenetics & Nuclear Signaling>DNA Damage & Repair

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality MUS81 Polyclonal Antibody.

Molecular Weight

Calculated MW: 61kDa Observed MW: 70kDa

Species Reactivity

Rabbit

Immunogen

Recombinant fusion protein of human MUS81 (NP_079404.3).

Cross Reactivity

Human,Mouse,Rat

Isotype

IgG

GeneID

UniProt ID

Purity

Affinity purification

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Storage Buffer

Buffer: PBS with 50% glycerol, pH7.3.

Applications

WB,IHC,IF

Dilution

WB 1:500 - 1:2000 IHC 1:50 - 1:100 IF 1:50 - 1:100

Product Description

This gene encodes a structure-specific endonuclease which belongs to the XPF/MUS81 endonuclease family and plays a critical role in the resolution of recombination intermediates during DNA repair after inter-strand cross-links, replication fork collapse, and DNA double-strand breaks. The encoded protein associates with one of two closely related essential meiotic endonuclease proteins (EME1 or EME2) to form a complex that processes DNA secondary structures. It contains an N-terminal DEAH helicase domain, an excision repair cross complementation group 4 (ERCC4) endonuclease domain, and two tandem C-terminal helix-hairpin-helix domains. Mice with a homozygous knockout of the orthologous gene have significant meiotic defects including the failure to repair a subset of DNA double strand breaks.

Synonyms

MUS81; SLX3; crossover junction endonuclease MUS81

Images

Western blot analysis of extracts of various cell lines, using MUS81 antibody.

Immunohistochemistry of paraffin-embedded rat brain using MUS81 antibody.

Immunohistochemistry of paraffin-embedded mouse brain using MUS81 antibody.

Specification

Quantity

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