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PPM1A Polyclonal Antibody

Catalog # Availability Size / Price Inquiry
APR26763N-1 50ul / $395
APR26763N-2 100ul / $495
APR26763N-3 200ul / $595

PPM1A Polyclonal Antibody

Brand

Leading Biology

Catalog Number

APR26763N

Product Type

Polyclonal Antibodies

Field of Research

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality PPM1A Polyclonal Antibody.

Molecular Weight

Calculated MW: 35kDa/42kDa/51kDa Observed MW: 42kDa

Species Reactivity

Rabbit

Immunogen

Recombinant fusion protein of human PPM1A (NP_066283.1).

Cross Reactivity

Human,Mouse,Rat

Isotype

IgG

GeneID

UniProt ID

Purity

Affinity purification

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Storage Buffer

Buffer: PBS with 50% glycerol, pH7.3.

Applications

WB,IF

Dilution

WB 1:500 - 1:2000 IF 1:50 - 1:200

Product Description

The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described.

Synonyms

PPM1A; PP2C-ALPHA; PP2CA; PP2Calpha; protein phosphatase 1A

Images

Western blot analysis of extracts of various cell lines, using PPM1A antibody.

Immunofluorescence analysis of HeLa cells using PPM1A antibody.

Specification

Quantity

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