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IMPA1 Polyclonal Antibody

Catalog # Availability Size / Price Inquiry
APR26475N-1 50ul / $395
APR26475N-2 100ul / $495
APR26475N-3 200ul / $595

IMPA1 Polyclonal Antibody

Brand

Leading Biology

Catalog Number

APR26475N

Product Type

Polyclonal Antibodies

Field of Research

Endocrine & Metabolism>Lipid Metabolism

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality IMPA1 Polyclonal Antibody.

Molecular Weight

Calculated MW: 21kDa/30kDa/36kDa Observed MW: 30kDa

Species Reactivity

Rabbit

Immunogen

Recombinant fusion protein of human IMPA1 (NP_005527.1).

Cross Reactivity

Human,Mouse,Rat

Isotype

IgG

GeneID

UniProt ID

Purity

Affinity purification

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Storage Buffer

Buffer: PBS with 50% glycerol, pH7.3.

Applications

WB,IHC,IF

Dilution

WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:10 - 1:100

Product Description

This gene encodes an enzyme that dephosphorylates myo-inositol monophosphate to generate free myo-inositol, a precursor of phosphatidylinositol, and is therefore an important modulator of intracellular signal transduction via the production of the second messengers myoinositol 1,4,5-trisphosphate and diacylglycerol. This enzyme can also use myo-inositol-1,3-diphosphate, myo-inositol-1,4-diphosphate, scyllo-inositol-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. This enzyme shows magnesium-dependent phosphatase activity and is inhibited by therapeutic concentrations of lithium. Inhibition of inositol monophosphate hydroylosis and subsequent depletion of inositol for phosphatidylinositol synthesis may explain the anti-manic and anti-depressive effects of lithium administered to treat bipolar disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. A pseudogene of this gene is also present on chromosome 8q21.13.

Synonyms

IMPA1; IMP; IMPA; MRT59; inositol monophosphatase 1

Images

Western blot analysis of extracts of various cell lines, using IMPA1 antibody.

Immunohistochemistry of paraffin-embedded rat kidney using IMPA1 antibody.

Immunohistochemistry of paraffin-embedded human colon using IMPA1 antibody.

Specification

Quantity

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