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MMP2 Polyclonal Antibody

Catalog # Availability Size / Price Inquiry
APR26370N-1 50ul / $395
APR26370N-2 100ul / $495
APR26370N-3 200ul / $595

MMP2 Polyclonal Antibody

Brand

Leading Biology

Catalog Number

APR26370N

Product Type

Polyclonal Antibodies

Field of Research

Cardiovascular>Angiogenesis

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality MMP2 Polyclonal Antibody.

Molecular Weight

Calculated MW: 65kDa/68kDa/73kDa Observed MW: 73kDa

Species Reactivity

Rabbit

Immunogen

Recombinant fusion protein of human MMP2 (NP_004521.1).

Cross Reactivity

Human,Mouse,Rat

Isotype

IgG

GeneID

UniProt ID

Purity

Affinity purification

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Storage Buffer

Buffer: PBS with 50% glycerol, pH7.3.

Applications

WB,IHC

Dilution

WB 1:500 - 1:2000IHC 1:50 - 1:200

Product Description

This gene is a member of the matrix metalloproteinase (MMP) gene family, that are zinc-dependent enzymes capable of cleaving components of the extracellular matrix and molecules involved in signal transduction. The protein encoded by this gene is a gelatinase A, type IV collagenase, that contains three fibronectin type II repeats in its catalytic site that allow binding of denatured type IV and V collagen and elastin. Unlike most MMP family members, activation of this protein can occur on the cell membrane. This enzyme can be activated extracellularly by proteases, or, intracellulary by its S-glutathiolation with no requirement for proteolytical removal of the pro-domain. This protein is thought to be involved in multiple pathways including roles in the nervous system, endometrial menstrual breakdown, regulation of vascularization, and metastasis. Mutations in this gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms.

Synonyms

MMP2; CLG4; CLG4A; MMP-2; MMP-II; MONA; TBE-1; matrix metallopeptidase 2

Images

Western blot analysis of extracts of U-87MG cells, using MMP2 antibody.

Immunohistochemistry of paraffin-embedded human stomach using MMP2 antibody.

Immunohistochemistry of paraffin-embedded mouse spleen using MMP2 antibody.

Specification

Quantity

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