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Location: Home > Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > [KO Validated] HDAC8 Polyclonal Antibody

[KO Validated] HDAC8 Polyclonal Antibody

Catalog # Availability Size / Price Inquiry
APR26139N-1 50ul / $395
APR26139N-2 100ul / $495
APR26139N-3 200ul / $595

[KO Validated] HDAC8 Polyclonal Antibody

Brand

Leading Biology

Catalog Number

APR26139N

Product Type

Polyclonal Antibodies

Field of Research

Cardiovascular>Heart

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality [KO Validated] HDAC8 Polyclonal Antibody.

Molecular Weight

Calculated MW: 15kDa/16kDa/17kDa/28kDa/29kDa/31kDa/41kDa Observed MW: 42kDa

Species Reactivity

Rabbit

Immunogen

Recombinant fusion protein of human HDAC8 (NP_060956.1).

Cross Reactivity

Human,Mouse,Rat

Isotype

IgG

GeneID

UniProt ID

Purity

Affinity purification

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Storage Buffer

Buffer: PBS with 50% glycerol, pH7.3.

Applications

WB,IHC,IF

Dilution

WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200

Product Description

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class I of the histone deacetylase family. It catalyzes the deacetylation of lysine residues in the histone N-terminal tails and represses transcription in large multiprotein complexes with transcriptional co-repressors. Multiple transcript variants encoding different isoforms have been found for this gene.

Synonyms

HDAC8; CDA07; CDLS5; HD8; HDACL1; MRXS6; RPD3; WTS; histone deacetylase 8

Images

Western blot analysis of extracts of various cell lines, using HDAC8 Antibody.

Western blot analysis of extracts from normal (control) and HDAC8 knockout (KO) HeLa cells, using HDAC8 antibody.

Immunohistochemistry of paraffin-embedded rat testis using HDAC8 antibody.

Specification

Quantity

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