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CLOCK Polyclonal Antibody

Catalog # Availability Size / Price Inquiry
APR25964N-1 50ul / $395
APR25964N-2 100ul / $495
APR25964N-3 200ul / $595

CLOCK Polyclonal Antibody

Brand

Leading Biology

Catalog Number

APR25964N

Product Type

Polyclonal Antibodies

Field of Research

Cardiovascular>Blood

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality CLOCK Polyclonal Antibody.

Molecular Weight

Calculated MW: 95kDa Observed MW: 70kDa

Species Reactivity

Rabbit

Immunogen

Recombinant fusion protein of human CLOCK (NP_004889.1).

Cross Reactivity

Human,Mouse,Rat

Isotype

IgG

GeneID

UniProt ID

Purity

Affinity purification

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Storage Buffer

Buffer: PBS with 50% glycerol, pH7.3.

Applications

WB

Dilution

WB 1:500 - 1:2000

Product Description

The protein encoded by this gene plays a central role in the regulation of circadian rhythms. The protein encodes a transcription factor of the basic helix-loop-helix (bHLH) family and contains DNA binding histone acetyltransferase activity. The encoded protein forms a heterodimer with ARNTL (BMAL1) that binds E-box enhancer elements upstream of Period (PER1, PER2, PER3) and Cryptochrome (CRY1, CRY2) genes and activates transcription of these genes. PER and CRY proteins heterodimerize and repress their own transcription by interacting in a feedback loop with CLOCK/ARNTL complexes. Polymorphisms in this gene may be associated with behavioral changes in certain populations and with obesity and metabolic syndrome. Alternative splicing results in multiple transcript variants.

Synonyms

CLOCK; KAT13D; bHLHe8; clock circadian regulator

Images

Western blot analysis of extracts of various cell lines, using CLOCK antibody.

Specification

Quantity

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