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MLKL Polyclonal Antibody

Catalog # Availability Size / Price Inquiry
APR25930N-1 50ul / $395
APR25930N-2 100ul / $495
APR25930N-3 200ul / $595

MLKL Polyclonal Antibody

Brand

Leading Biology

Catalog Number

APR25930N

Product Type

Polyclonal Antibodies

Field of Research

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality MLKL Polyclonal Antibody.

Molecular Weight

Calculated MW: 53kDa/54kDa Observed MW: 54kDa

Species Reactivity

Rabbit

Immunogen

Recombinant protein of mouse MLKL

Cross Reactivity

Human,Mouse

Isotype

IgG

GeneID

UniProt ID

Purity

Affinity purification

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Storage Buffer

Buffer: PBS with 50% glycerol, pH7.3.

Applications

WB,IHC,IF

Dilution

WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200

Product Description

This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene.

Synonyms

MLKL; hMLKL; mixed lineage kinase domain-like protein

Images

Western blot analysis of extracts of various cell lines, using MLKL antibody.

Specification

Quantity

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