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MCM4 Polyclonal Antibody

Catalog # Availability Size / Price Inquiry
APR25075N-1 50ul / $395
APR25075N-2 100ul / $495
APR25075N-3 200ul / $595

MCM4 Polyclonal Antibody

Brand

Leading Biology

Catalog Number

APR25075N

Product Type

Polyclonal Antibodies

Field of Research

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality MCM4 Polyclonal Antibody.

Molecular Weight

Calculated MW: 96kDa Observed MW: 105kDa

Species Reactivity

Rabbit

Immunogen

A synthetic peptide of human MCM4

Cross Reactivity

Human,Mouse,Rat

Isotype

IgG

GeneID

UniProt ID

Purity

Affinity purification

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Storage Buffer

Buffer: PBS with 50% glycerol, pH7.3.

Applications

WB,IHC

Dilution

WB 1:500 - 1:2000 IHC 1:50 - 1:200

Product Description

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 6 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of this protein by CDC2 kinase reduces the DNA helicase activity and chromatin binding of the MCM complex. This gene is mapped to a region on the chromosome 8 head-to-head next to the PRKDC/DNA-PK, a DNA-activated protein kinase involved in the repair of DNA double-strand breaks. Alternatively spliced transcript variants encoding the same protein have been reported.

Synonyms

MCM4; CDC21; CDC54; NKCD; NKGCD; P1-CDC21; hCdc21; DNA replication licensing factor MCM4

Images

Western blot analysis of extracts of various cell lines, using MCM4 antibody.

Immunohistochemistry of paraffin-embedded rat pancreas using MCM4 Antibody.

Immunohistochemistry of paraffin-embedded human gastric cancer using MCM4 Antibody.

Specification

Quantity

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