> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > PFKFB4 Polyclonal AntibodyBrand |
Leading Biology | Catalog Number |
APR24079N |
Product Type |
Polyclonal Antibodies | Field of Research |
Endocrine & Metabolism>Warburg Effect |
Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality PFKFB4 Polyclonal Antibody.
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Molecular Weight |
Calculated MW:
49kDa/50kDa/54kDa
Observed MW:
Refer to figures
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Species Reactivity |
Rabbit
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Immunogen |
A synthetic peptide of human PFKFB4
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Cross Reactivity |
Human,Mouse,Rat
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Isotype |
IgG
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GeneID |
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UniProt ID |
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Purity |
Affinity purification |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Storage Buffer |
Buffer: PBS, pH7.3.
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Applications |
WB
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Dilution |
WB 1:500 - 1:1000
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Product Description |
The protein encoded by this gene is one of four bifunctional kinase/phosphatases that regulate the concentration of the glycolytic byproduct fructose-2,6-bisphosphate (F2,6BP). The encoded protein is highly expressed in cancer cells and is induced by hypoxia. This protein is essential to the survival of cancer cells under conditions of hypoxia, because it increases the amount of F2,6BP and ATP at a time when the cell cannot produce much of them. This finding suggests that this protein may be a good target for disruption in cancer cells, hopefully imperiling their survival. Several transcript variants encoding different isoforms have been found for this gene.
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Synonyms |
PFKFB4; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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