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CDK4 Polyclonal Antibody

Catalog # Availability Size / Price Inquiry
APR23376N-1 50ul / $395
APR23376N-2 100ul / $495
APR23376N-3 200ul / $595

CDK4 Polyclonal Antibody

Brand

Leading Biology

Catalog Number

APR23376N

Product Type

Polyclonal Antibodies

Field of Research

Cell Biology & Developmental Biology>Cell Cycle

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality CDK4 Polyclonal Antibody.

Molecular Weight

Calculated MW: 20kDa/33kDa Observed MW: 34kDa

Species Reactivity

Rabbit

Immunogen

A synthetic peptide of human CDK4.

Cross Reactivity

Human,Mouse,Rat

Isotype

IgG

GeneID

UniProt ID

Purity

Affinity purification

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Storage Buffer

Buffer: PBS with 50% glycerol, pH7.3.

Applications

WB,IHC,IF,IP

Dilution

WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200

Product Description

The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported.

Synonyms

CDK4; CMM3; PSK-J3; cyclin-dependent kinase 4

Images

Western blot analysis of extracts of various cell lines, using CDK4 antibody.

Specification

Quantity

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