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CFB Polyclonal Antibody

Catalog # Availability Size / Price Inquiry
APR19842N-1 50ul / $395
APR19842N-2 100ul / $495
APR19842N-3 200ul / $595

CFB Polyclonal Antibody

Brand

Leading Biology

Catalog Number

APR19842N

Product Type

Polyclonal Antibodies

Field of Research

Immunology & Inflammation>Cell Intrinsic Innate Immunity Signaling Pathway

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality CFB Polyclonal Antibody.

Molecular Weight

Calculated MW: 68kDa/85kDa Observed MW: 100kDa

Species Reactivity

Rabbit

Immunogen

Recombinant fusion protein of human CFB (NP_001701.2).

Cross Reactivity

Mouse,Rat

Isotype

IgG

GeneID

UniProt ID

Purity

Affinity purification

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Storage Buffer

Buffer: PBS with 50% glycerol, pH7.3.

Applications

WB

Dilution

WB 1:1000 - 1:2000

Product Description

This gene encodes complement factor B, a component of the alternative pathway of complement activation. Factor B circulates in the blood as a single chain polypeptide. Upon activation of the alternative pathway, it is cleaved by complement factor D yielding the noncatalytic chain Ba and the catalytic subunit Bb. The active subunit Bb is a serine protease which associates with C3b to form the alternative pathway C3 convertase. Bb is involved in the proliferation of preactivated B lymphocytes, while Ba inhibits their proliferation. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. This cluster includes several genes involved in regulation of the immune reaction. Polymorphisms in this gene are associated with a reduced risk of age-related macular degeneration. The polyadenylation site of this gene is 421 bp from the 5' end of the gene for complement component 2.

Synonyms

CFB; AHUS4; ARMD14; BF; BFD; CFAB; CFBD; FB; FBI12; GBG; H2-Bf; PBF2; complement factor B

Images

Western blot analysis of extracts of rat serum, using CFB antibody.

Specification

Quantity

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