We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality alpha1D-Adrenoceptor (extracellular) antibody.

59354 Da

Rabbit

Human, Mouse, Rat

Peptide (C)EPVPPDERF*SGITEE, corresponding to amino acid residues? 231-245 of rat ?±1D-Adrenoceptor with replacement of cysteine 240? (C240) with serine (*S) (Accession P23944 ). 3rd extracellular loop.

Adrenoceptors (also called Adrenergic receptors) are the receptors for the catecholamines adrenaline and noradrenaline (called epinephrine and norepinephrine in the United States).Adrenaline and noradrenaline play important roles in the control of blood pressure, myocardial contractile rate and force, airway reactivity, and a variety of metabolic and central nervous system functions. The Adrenoceptors are members of the G-protein coupled receptor (GPCR) superfamily of membrane proteins. They share a common structure of seven putative transmembrane domains, an extracellular amino terminus, and a cytoplasmic carboxyl terminus.The Adrenoceptors are divided into three types: α1, α2 and β-Adrenoceptors. Each type is further divided into at least three subtypes: α1A, α1B, α1D, α2A, α2B, α2C, β1, β2, β31,2. The Adrenoceptors are expressed in nearly all peripheral tissues and in the central nervous system1,2. α1-Adrenergic Receptors play an important role in the physiological response to epinephrine and norepinephrine, particularly in the cardiovascular system. All three cloned α1 receptors (α1A, α1B, and α1D) couple to Gq/11. While their cellular distribution is clear, their functional role is less so due to the lack of specific agonists/antagonists3. As these receptors lack specific agonists/antagonists knock-out mice studies have most significantly shed light on the cellular role of Adrenoceptors. Individual α1-Adrenoceptor knock-out mice do not display physical abnormalities in general. Similar knock-out studies indicate that all α1 subtypes seem to be involved in the regulation of blood pressure3. Also, studies indicate that α1D-Adrenoceptor seems to play an important role in aortic contraction4, renal function, nociception, basal locomotor activity3 as well as bladder contraction5. Abgent is pleased to offer a highly specific antibody directed against an extracellular epitope of rat α1D-Adrenoceptor. Anti-α1D-Adrenoceptor (extracellular) antibody (#AG1377) can be used in western blot, indirect flow cytometry and immunohistochemical applications. It has been designed to recognize α1D-Adrenoceptor from mouse, rat and human samples.

Affinity purified antibody, Liquid

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

WB, IHC, FC

WB~~1:200-1:2000 IHC~~1:100

Alpha-1D adrenergic receptor, Alpha-1A adrenergic receptor, Alpha-1D adrenoreceptor, Alpha-1D adrenoceptor, RA42, Adra1d, Adra1a

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