• Account
  • Account
    Inquiries
    0

    Inquired items

    0 items total Subtotal:$ 0
  • 会员中心
    Cart

    Added items

    0items total Subtotal:$ 0

All Departments

Location: Home > Antigens, Antibodies, ELISA, Western Blo > Primary Antibody > Polyclonal Antibodies > Human p75NTR (intracellular) Antibody

Human p75NTR (intracellular) Antibody

Catalog # Availability Size / Price Inquiry
APR12425G  In Stock 50 μl / $695

Human p75NTR (intracellular) Antibody

Brand

Leading Biology

Catalog Number

APR12425G

Product Type

Polyclonal Antibodies

Field of Research

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality Human p75NTR (intracellular) antibody.

Molecular Weight

45183 Da

Host

Rabbit

Species Reactivity

Human, Rat

Target

Peptide CKQNKQGANSRPVNQT corresponding to amino acid residues 278-293 of human p75NTR (SwissProt accession P08138).???? Intracellular, juxtamembrane domain.

GeneID

UniProt ID

Summary

The p75NTR receptor is a member of the TNF receptor superfamily. p75NTR, like all the superfamily members is a type I transmembrane protein with tandem cysteine-rich domains in the extracellular portion and a intracellular death domain.p75NTR binds its ligands as a homodimer but can also form heterodimers with other receptors such as TrkA, TrkB, TrkC, Nogo receptor and sortilin. The precise multimeric receptor complex formed between p75NTR and the other receptors will determine the ligand being recognized (see below) and the biological response to its binding.As its name implies, p75NTR binds all the neurotrophins (NGF, BDNF, NT-3 and NT-4) with similar nM affinities. Co-expression of p75NTR with the Trk receptors enhances the ability to bind and respond to the specific neurotrophin and induces cell survival.On the other hand, it has recently been demonstrated that p75NTR binds with high affinity to the unprocessed form of NGF (proNGF) probably as a complex with sortilin and this leads to cell death by apoptosis. Finally, a multimeric complex of p75NTR and Nogo receptor binds myelin proteins such as Nogo-66, MAG and OmgP resulting in inhibition of axonal growth.We have now developed a new antibody specific for the p75NTR, Anti-Human p75NTR (intracellular) (#AG1177). This antibody was raised against a highly conserved epitope located in the juxtamembrane domain of the human p75NTR intracellular region. The antibody works equally well in mouse and rat samples.

Form

Affinity purified antibody, Liquid

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Applications

WB

Dilution

WB~~1:200-1:2000 IHC~~1:200

Synonyms

Tumor necrosis factor receptor superfamily member 16, Gp80-LNGFR, Low affinity neurotrophin receptor p75NTR, Low-affinity nerve growth factor receptor, NGF receptor, p75 ICD, CD271, NGFR, TNFRSF16

Images

Western blot analysis of rat brain membranes: 1. Anti-Human p75<sup> NTR </sup>(intracellular) antibody ( APR12425G), (1:200). 2. Anti-Human p75<sup> NTR </sup>(intracellular) antibody, preincubated with the control peptide antigen.

Western blot analysis of human melanoma cells A875: 1. Anti-Human p75<sup> NTR</sup> (intracellular) antibody ( APR12425G), (1:200). 2. Anti-Human p75<sup> NTR </sup>(intracellular) antibody, preincubated with the control peptide antigen.

Expression of p75<sup>NTR</sup> in mouse hippocampus A. Mouse hippocampal sections (frozen) were stained with Anti-Human p75<sup>NTR</sup>-intracellular antibody ( APR12425G) (1:200). p75<sup>NTR</sup> (green) appeared in a subset of astrocytes. B. Astrocytes were visualized with Anti - glial fibrillary acidic protein (GFAP) antibody (red). C. A merge of the two images demonstrates appearance of p75<sup>NTR</sup> mainly in stratum radiatum (SOR) and only in a few astrocytes in the alveus (AL).

Specification

Quantity

Related Products

Select Brand Catalog No. Product Name Pack Size Type Field of Research Specification Quantity Price(USD)
1 Leading Biology APR03864G CELA3B Antibody (N-term) 100 μl Polyclonal Antibodies
$495.00 Add Ask
2 Leading Biology APR03440G ITGA11 Antibody (N-term) 100 μl Polyclonal Antibodies
$495.00 Add Ask
3 Leading Biology APR04506G PCOLCE2 Antibody (Center) 100 μl Polyclonal Antibodies
$495.00 Add Ask
4 Leading Biology APR04726G FOXN4 Antibody (Center) 100 μl Polyclonal Antibodies
$495.00 Add Ask
5 Leading Biology APR03818G MID1 Antibody (C-term) 100 μl Polyclonal Antibodies
$495.00 Add Ask
6 Leading Biology APC00044G SARS virus PUPM Antibody (C-term) 100 μl Polyclonal Antibodies
$495.00 Add Ask
Contact Us

This item has successfully been added to your cart!

You have 0 item in your cart

Your inquiry has successfully been added to your list!

You have 0 item in your inquiry list