> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > sloBeta3 (KCNMB3) (extracellular) AntibodyBrand |
Leading Biology | Catalog Number |
APR13405G |
Product Type |
Polyclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality sloBeta3 (KCNMB3) (extracellular) antibody.
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Molecular Weight |
26447 Da
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Host |
Rabbit
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Species Reactivity |
Mouse, Rat
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Target |
Peptide (C)HYDEEAIRTNPK, corresponding to amino acid residues 134- 145 of rat Slo??3 (Accession A7VL23). Extracellular loop.Not recommended for human samples.
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GeneID |
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UniProt ID |
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Summary |
Large-conductance, voltage- and Ca2+-activated K+ channels, also known as the BK channels, are widely expressed channels that couple changes in submembrane Ca2+ concentration to the regulation of electrical excitability1. BK channels are formed from four α-subunits arising from the Slowpoke (Slo) gene product2. In addition, in smooth muscle and cochlea, an accessory β-subunit can regulate BK channel gating profoundly. At present, four β subunits have been cloned in mammals. β Subunits alter the Ca2+ sensitivity and gating kinetics of BK channels, greatly contributing to BK channel diversity. On the other hand, they modify the BK channel pharmacological properties, changing toxin binding and acting as receptors for drugs3.Regulatory β subunits share a putative membrane topology, with two transmembrane segments connected by a 120- residue extracellular loop and with NH2 and COOH terminals oriented toward the cytoplasm4. Each β subunit has a tissue-specific expression and modulates channel function uniquely which provides a major mechanism for diverse BK channel phenotypes in various tissues.β3 is highly expressed in kidney, heart, and brain5. The β3 gene (KCNMB3) associates with Slo1 α subunits and regulate BK channel function. In humans, the β3 gene contains four N-terminal alternative exons that produce four functionally distinct β3 subunits, β3a-d. Three variants, β3a-c, exhibit kinetically distinct inactivation behaviors6. A mutation in the β3 gene is linked to idiopathic epilepsy7.
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Form |
Affinity purified antibody, Liquid |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB
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Dilution |
WB~~1:200-1:2000
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Synonyms |
Calcium-activated potassium channel subunit beta-3, Calcium-activated potassium channel subfamily M subunit beta-3, Maxi K channel subunit beta-3, Kcnmb3 {ECO:0000312|EMBL:BAF799241}
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Images |
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Specification |
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Quantity |
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Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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