We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality Prokineticin Receptor-2 (extracellular) antibody.

43603 Da

Rabbit

Rat

Peptide (C)DQNGNTSFAPDLN, corresponding to amino acid residues 3-15 of rat Prokineticin Receptor 2 (Accession Q8R415). Extracellular, N-terminus.

The Prokineticins (PK1 and PK2) are a pair of cysteine-rich secreted peptides with broad physiological functions including gastrointestinal motility, angiogenesis, hematopoiesis and circadian rhythms regulation.The biological effects of the PK1 and PK2 are mediated by two highly homologous receptors termed Prokineticin Receptor 1 (PKR1) and Prokineticin Receptor 2 (PKR2) that belong to the 7-transmembrane domain, G protein-coupled receptor (GPCR) superfamily. Both PK ligands activate the two PK receptors with similar potency.1PKR2 receptors couple to Gq/G11 proteins leading to phospholipase C activation, inositol phosphate production and calcium mobilization.The distribution of PKR2 is relatively restricted with high expression levels in the brain, spinal cord and dorsal root ganglions, in organs of the reproductive system and in endocrine tissues such as the thyroid, pituitary and adrenal glands.1The PK2 ligand has been shown to be involved in the regulation of circadian rhythms of physiological and behavioral processes in mammals, probably through signaling via PKR2 which is highly expressed in the suprachiasmatic nucleus (SCN), an area of the brain that controls circadian rhythm processes.2In addition, loss of function mutations in the PKR2 gene have been associated with Kallmann Syndrome, a condition characterized by idiopathic hypogonadotropic hypogonadism (IHH) in combination with anosmia, a compromised sense of smell.3Abgent is pleased to offer a highly specific antibody directed against an epitope located at the extracellular N-terminus domain of the rat PKR2 receptor. The epitope is specific for PKR2 and will not cross-react with the closely related PKR1 receptor. Anti-Prokineticin Receptor 2 (extracellular) antibody (#AG1055) can be used in Western blot analysis and immunohistochemical applications, and recognizes PKR2 from rat samples.

Affinity purified antibody, Liquid

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

WB

WB~~1:200-1:2000 IHC~~1:100

Prokineticin receptor 2, PK-R2, G-protein coupled receptor 73-like 1, G-protein coupled receptor I5E, Prokr2, Gpr73l1, Pkr2

Product Datasheet Protocol