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ARSB Antibody

Catalog # Availability Size / Price Inquiry
APG02001G 0.1 mg / $695

ARSB Antibody

Brand

Leading Biology

Catalog Number

APG02001G

Product Type

Polyclonal Antibodies

Field of Research

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality ARSB antibody .

Molecular Weight

Predicted: 59 kDa Observed: 57kDa

Cellular Localization

Antigen Cellular Localization: Lysosome. Cell surface {ECO:0000250|UniProtKB:P50429}

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Target

ARSB; ARSB antibody is human, mouse and rat reactive. At least two isoforms of ARSB are known to exist; this antibody only recognizes the longest isoform.

Isotype

IgG

GeneID

UniProt ID

Function

Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation (PubMed:19306108). Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium (PubMed:19306108). In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels (By similarity).

Summary

Aryl sulfatase B (ARSB) forms a homodimer that hydrolyzes sulfate groups of N-Acetyl-D-galactosamine, chondriotin sulfate, and dermatan sulfate (1). ARSB localizes to the lysozyme as well as to the extracellular matrix (2). Mucopolysaccharidosis type VI is an autosomal recessive lysosomal storage disorder resulting from a deficiency of arylsulfatase B (3), and can be treated with exogenous ARSB (4).

Form

Liquid

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Applications

WB, IHC-P, IF, E

Images

Western blot analysis of ARSB in mouse lung tissue lysate with ARSB antibody at (A) 1 and (B) 2 μg/ml.

Immunohistochemistry of ARSB in human lung tissue with ARSB antibody at 2.5 μg/mL.

Immunofluorescence of ARSB in human lung tissue with ARSB antibody at 20 μg/mL.

Specification

Quantity

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