> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > West Nile Virus Core AntibodyBrand |
Leading Biology | Catalog Number |
AMM05447G |
Product Type |
Polyclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality West Nile Virus Core antibody.
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Molecular Weight |
380110 Da
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Cellular Localization |
Antigen Cellular Localization:
Capsid protein C: Virion. Host membrane; Single-pass membrane protein Envelope protein E: Virion membrane; Multi-pass membrane protein. Host endoplasmic reticulum membrane {ECO:0000255|PROSITE- ProRule:PRU00860}; Multi-pass membrane protein Non-structural protein 2A: Host endoplasmic reticulum membrane {ECO:0000255|PROSITE-ProRule:PRU00860}; Multi- pass membrane protein Serine protease NS3: Host endoplasmic reticulum membrane {ECO:0000255|PROSITE-ProRule:PRU00860}; Peripheral membrane protein {ECO:0000255|PROSITE- ProRule:PRU00860}; Cytoplasmic side {ECO:0000255|PROSITE- ProRule:PRU00860}. Note=Remains non-covalently associated to NS3 protease. {ECO:0000255|PROSITE-ProRule:PRU00860} Non-structural protein 4B: Host endoplasmic reticulum membrane {ECO:0000255|PROSITE-ProRule:PRU00860}; Multi- pass membrane protein
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Host |
Rabbit
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Species Reactivity |
Virus
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Target |
WNVgp1;
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Isotype |
IgG
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GeneID |
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UniProt ID |
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Function |
Capsid protein C self-assembles to form an icosahedral capsid about 30 nm in diameter. The capsid encapsulates the genomic RNA (By similarity).
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Summary |
West Nile Virus Core Antibody: West Nile Virus (WNV) is a member of the Flaviviridae, a plus-stranded virus family that includes St. Louis encephalitis virus, yellow fever virus, and Dengue virus. WNV was initially isolated in 1937 in the West Nile region of Uganda and has become prevalent in Africa, Asia, and Europe. It has rapidly spread across the United States with cases being observed in every continental state. Virus particles consist of a dense core made up of the core/capsid protein encapsulating the RNA genome surrounded by a membrane envelope embedded with envelope and matrix proteins which play a major role for WNV entry into target cells. The viral core protein is thought to contribute to the WNV-associated inflammation via apoptosis induced though the caspase-9 pathway as delivery of core gene delivery into the striatum of mouse brain and skeletal muscle resulted in cell death and inflammation.
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Form |
Liquid |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, ICC, E
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Synonyms |
West Nile Virus Core Antibody: Genome polyprotein, Core protein, NS1, Anchored core protein C
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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