> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > CaValpha2delta-1 (extracellular) AntibodyBrand |
Leading Biology | Catalog Number |
AMM05701G |
Product Type |
Polyclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality CaValpha2delta-1 (extracellular) antibody.
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Molecular Weight |
125043 Da
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Host |
Rabbit
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Species Reactivity |
Human, Rat
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Target |
Peptide EPFPSAVTIKSWVDK(C), corresponding to amino acid residues 1-15 of ?±2 subunit (residues 27-41 of rabbit ?±2??1 precursor) (Accession P13806).???? Extracellular, N-terminus.
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GeneID |
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UniProt ID |
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Summary |
The α2δ1 protein is an auxiliary subunit of the CaV (voltage dependent calcium) channel multimer complex. Four α2δ isoforms were identified in mammalian genoms and they share some sequence as well as structure homology.1 The protein product of the gene encoding α2δ is complex, it includes two seperated proteins the extracellular α2 linked by disulphide bridges to the membrane sppaning (single transmembrane helix)δ subunit. α2δ1 subunit is highly expressed in skeletal muscle and brain. Its expression along with a pore forming CaV α1 subunit, result in larger CaV currents, probably due to improoved trafficing of the α1 subunit to the plasma membrane.1-2 α2δ1 subunit was shown to be the target of the antiepileptic and anelgestic drug gabapentin.3
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Form |
Affinity purified antibody, Liquid |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB
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Dilution |
WB~~1:200-1:2000
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Synonyms |
Voltage-dependent calcium channel subunit alpha-2/delta-1, Voltage-gated calcium channel subunit alpha-2/delta-1, Voltage-dependent calcium channel subunit alpha-2-1, Voltage-dependent calcium channel subunit delta-1, CACNA2D1, CACNL2A, CCHL2A
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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