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Location: Home > Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > rat TRPV1 (extracellular) Antibody

rat TRPV1 (extracellular) Antibody

Catalog # Availability Size / Price Inquiry
APR13072G 50 μl / $695

rat TRPV1 (extracellular) Antibody

Brand

Leading Biology

Catalog Number

APR13072G

Product Type

Polyclonal Antibodies

Field of Research

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality rat TRPV1 (extracellular) antibody.

Molecular Weight

94948 Da

Host

Rabbit

Species Reactivity

Rat

Target

Peptide (C)NSLPMESTPHK*SRGS,??corresponding to amino acid residues 605-619 of rat TRPV1 with replacement of cysteine 616 (C616) with serine (*S) (Accession O35433). 3rd extracellular loop.Recognizes TRPV1 from rat samples only.

GeneID

UniProt ID

Summary

TRP channels are a large family (about 28 genes) of plasma membrane, non-selective cationic channels that are either specifically or ubiquitously expressed in excitable and non-excitable cells.1According to IUPHAR the TRP family comprises of three main subfamilies on the basis of sequence homology; TRPC, TRPM and TRPV (to date, three extra subfamilies are considered to belong to the TRP family; the TRPA, TRPML, and TRPP).1-4 The TRPV subfamily consists of six members, TRPV1-6.5TRPV1 channel has many activators among them heat, protons, vanilloids like capsaicin, reiniferatoxin (RTX), and lipids. This channel is associated with tissue injury and inflammation.6,7TRPV1 is expressed predominantly in nociceptors and in sensory neurons.Recent studies demonstrated involvement of TRPV1 in apoptosis where inhibition of the receptor prevented apoptosis.8,9Abgent is pleased to offer a highly specific antibody directed against an extracellular epitope of the rat TRPV1 channel. Anti-Rat TRPV1 (extracellular) antibody (#AG1453) can be used for western blot and immunohistochemistry applications. It has been designed to recognize only rat TRPV1 samples.

Form

Affinity purified antibody, Liquid

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Applications

WB, LCI

Dilution

WB~~1:200-1:2000 IHC~~1:100

Synonyms

Transient receptor potential cation channel subfamily V member 1, TrpV1, Capsaicin receptor, Osm-9-like TRP channel 1, OTRPC1, Vanilloid receptor 1, Vanilloid receptor type 1-like, Trpv1, Vr1, Vr1l

Images

Western blot analysis of TRPV1 in rat DRG: 1. Anti-R at TRPV1 (extracellular) antibody ( APR13072G), (1:200). 2. Anti-Rat TRPV1 (extracellular) antibody, preincubated with the control peptide antigen.

Expression of TRPV1 in rat DRG Immunohistochemical staining of rat dorsal root ganglion (DRG) frozen sections using Anti-Rat TRPV1 (extracellular ) antibody ( APR13072G), (1:100) followed by goat anti-rabbit-ATTO-594 secondary antibody (red). TRPV1 is expressed in medium and small DRG neurons. Hoechst 33342 is used as the counterstain (blue).

Specification

Quantity

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