> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > rat TRPV1 (extracellular) AntibodyBrand |
Leading Biology | Catalog Number |
APR13072G |
Product Type |
Polyclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality rat TRPV1 (extracellular) antibody.
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Molecular Weight |
94948 Da
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Host |
Rabbit
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Species Reactivity |
Rat
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Target |
Peptide (C)NSLPMESTPHK*SRGS,??corresponding to amino acid residues 605-619 of rat TRPV1 with replacement of cysteine 616 (C616) with serine (*S) (Accession O35433). 3rd extracellular loop.Recognizes TRPV1 from rat samples only.
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GeneID |
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UniProt ID |
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Summary |
TRP channels are a large family (about 28 genes) of plasma membrane, non-selective cationic channels that are either specifically or ubiquitously expressed in excitable and non-excitable cells.1According to IUPHAR the TRP family comprises of three main subfamilies on the basis of sequence homology; TRPC, TRPM and TRPV (to date, three extra subfamilies are considered to belong to the TRP family; the TRPA, TRPML, and TRPP).1-4 The TRPV subfamily consists of six members, TRPV1-6.5TRPV1 channel has many activators among them heat, protons, vanilloids like capsaicin, reiniferatoxin (RTX), and lipids. This channel is associated with tissue injury and inflammation.6,7TRPV1 is expressed predominantly in nociceptors and in sensory neurons.Recent studies demonstrated involvement of TRPV1 in apoptosis where inhibition of the receptor prevented apoptosis.8,9Abgent is pleased to offer a highly specific antibody directed against an extracellular epitope of the rat TRPV1 channel. Anti-Rat TRPV1 (extracellular) antibody (#AG1453) can be used for western blot and immunohistochemistry applications. It has been designed to recognize only rat TRPV1 samples.
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Form |
Affinity purified antibody, Liquid |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, LCI
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Dilution |
WB~~1:200-1:2000
IHC~~1:100
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Synonyms |
Transient receptor potential cation channel subfamily V member 1, TrpV1, Capsaicin receptor, Osm-9-like TRP channel 1, OTRPC1, Vanilloid receptor 1, Vanilloid receptor type 1-like, Trpv1, Vr1, Vr1l
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Images |
Western blot analysis of TRPV1 in rat DRG: 1. Anti-R at TRPV1 (extracellular) antibody ( APR13072G), (1:200). 2. Anti-Rat TRPV1 (extracellular) antibody, preincubated with the control peptide antigen.
Expression of TRPV1 in rat DRG Immunohistochemical staining of rat dorsal root ganglion (DRG) frozen sections using Anti-Rat TRPV1 (extracellular ) antibody ( APR13072G), (1:100) followed by goat anti-rabbit-ATTO-594 secondary antibody (red). TRPV1 is expressed in medium and small DRG neurons. Hoechst 33342 is used as the counterstain (blue). |
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Specification |
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Quantity |
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Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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