> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > human CaV1.2 AntibodyBrand |
Leading Biology | Catalog Number |
APR07894G |
Product Type |
Polyclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality human CaV1.2 antibody.
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Molecular Weight |
248977 Da
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Host |
Rabbit
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Species Reactivity |
Human, Mouse, Rat
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Target |
Peptide VNENTRMYIPEENHQ(C), corresponding to amino acid??residues 2-15 of human Cav1.2 (exon 1B) (Accession Q13936). Intracellular, N-terminus.The antibody recognizes mouse CaV1.2, splice variants P22002-4 and P22002-5 of rat CaV1.2 and splice variant P15381-4 of rabbit CaV1.2.
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GeneID |
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UniProt ID |
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Summary |
All L-type calcium channels are encoded by one of the CaV1 channel genes. These channels play a major role as a Ca2+ entry pathway in skeletal cardiac and smooth muscles as well as in neurons, endocrine cells and possibly in non-excitable cells such as hematopoetic and epithelial cells. All CaV1 channels are influenced by dihydropyridines (DHP) and are also referred to as DHP receptor. While the CaV1.1 and CaV1.4 isoforms are expressed in restricted tissues (skeletal muscle and retina, respectively), the expression of CaV1.2 is ubiquitous and CaV1.3 channels are found in heart, brain and pancreas. Several peptidyl toxins are described that are specific L-type channels blockers, but so far no selective blocker for one of the CaV1 isoforms have been described. These include the Mamba toxins Calcicludine (#C-650), Calciseptine (#C-500) and FS-2 (#F-700).
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Form |
Affinity purified antibody, Liquid |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB
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Dilution |
WB~~1:200-1:2000
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Synonyms |
Voltage-dependent L-type calcium channel subunit alpha-1C, Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle, Voltage-gated calcium channel subunit alpha Cav12, CACNA1C, CACH2, CACN2, CACNL1A1, CCHL1A1
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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