> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > P2X7 Receptor (extracellular) AntibodyBrand |
Leading Biology | Catalog Number |
APR12692G |
Product Type |
Polyclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality P2X7 Receptor (extracellular) antibody.
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Molecular Weight |
68388 Da
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Host |
Rabbit
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Species Reactivity |
Human, Mouse, Rat
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Target |
Peptide KKGWMDPQSKGIQTGRC, corresponding to amino acid residues 136-152 of mouse??P2X7 Receptor (Accession number Q9Z1M0). Extracellular loop.
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GeneID |
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UniProt ID |
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Summary |
The P2X7 receptor is a member of the ionotropic P2X receptor family that is activated by ATP. To date, this family is composed of seven cloned receptor subtypes, named P2X1-P2X7. The different P2X receptors show distinct expression patterns. P2X1-6 have been found in thecentral and peripheral nervous system, while the P2X7 receptor is found in cells of the immune system, particularly antigen presenting cells, and microglia. The P2X7 receptor mediates the release of proinflamatory cytokines, stimulation of transcription factors and may also have an importantrole in apoptosis.1-3Different techniques have been used to characterize the P2X7 receptor.Most of them investigated pores, ion channels (electrophysiology) and membrane alterations(calcium microfluorometry, dye uptake, membrane depolarization and ion influx analysis).With the introduction of flow cytometry, it is now possible to analyze multiple cell parameters such as cell cycle, cell membrane alteration, calcium influx and cell phenotype.4
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Form |
Affinity purified antibody, Liquid |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB
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Dilution |
WB~~1:200-1:2000
IHC~~1:100
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Synonyms |
P2X purinoceptor 7, P2X7, ATP receptor, P2Z receptor, Purinergic receptor, P2rx7, P2x7
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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