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Location: Home > Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > ZIC2 antibody - C-terminal region

ZIC2 antibody - C-terminal region

Catalog # Availability Size / Price Inquiry
APR14036G 50 μg / $545

ZIC2 antibody - C-terminal region

Brand

Leading Biology

Catalog Number

APR14036G

Product Type

Polyclonal Antibodies

Field of Research

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality ZIC2 antibody - C-terminal region.

Molecular Weight

55kDa

Cellular Localization

Antigen Cellular Localization: Nucleus. Cytoplasm. Note=Localizes in the cytoplasm in presence of MDFIC overexpression. Both phosphorylated and unphosphorylated forms are localized in the nucleus (By similarity).

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

GeneID

UniProt ID

Function

Acts as a transcriptional activator or repressor. Plays important roles in the early stage of organogenesis of the CNS. Activates the transcription of the serotonin transporter SERT in uncrossed ipsilateral retinal ganglion cells (iRGCs) to refine eye-specific projections in primary visual targets. Its transcriptional activity is repressed by MDFIC. Involved in the formation of the ipsilateral retinal projection at the optic chiasm midline. Drives the expression of EPHB1 on ipsilaterally projecting growth cones. Binds to the minimal GLI-consensus sequence 5'-TGGGTGGTC-3'. Associates to the basal SERT promoter region from ventrotemporal retinal segments of retinal embryos.

Form

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Applications

WB, IHC

Synonyms

Zinc finger protein ZIC 2, Zinc finger protein of the cerebellum 2, ZIC2

Images

Human Skin

WB Suggested Anti-ZIC2 Antibody Titration: 0.2-1 μg/ml Positive Control: HepG2 cell lysate

Specification

Quantity

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