> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > DBP5 / SON Antibody (N-Terminus)Brand |
Leading Biology | Catalog Number |
APR07519G |
Product Type |
Polyclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality DBP5 / SON antibody (N-Terminus).
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Molecular Weight |
263830 Da
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Cellular Localization |
Antigen Cellular Localization:
Nucleus speckle. Note=Colocalizes with the pre-mRNA splicing factor SRSF2
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Host |
Goat
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Species Reactivity |
Human, Mouse, Rat, Rabbit, Monkey, Bovine, Horse, Guinea Pig, Dog
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Target |
Human SON. This antibody is expected to recognize reported isoforms B ( NP_115571.1) and F (NP_620305.1).
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Symbol |
C21orf50, DBP5, KIAA1019, NREBP
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GeneID |
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UniProt ID |
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Function |
RNA-binding protein that acts as a mRNA splicing cofactor by promoting efficient splicing of transcripts that possess weak splice sites. Specifically promotes splicing of many cell-cycle and DNA-repair transcripts that possess weak splice sites, such as TUBG1, KATNB1, TUBGCP2, AURKB, PCNT, AKT1, RAD23A, and FANCG. Probably acts by facilitating the interaction between Serine/arginine-rich proteins such as SRSF2 and the RNA polymerase II. Also binds to DNA; binds to the consensus DNA sequence: 5'- GA[GT]AN[CG][AG]CC-3'. May indirectly repress hepatitis B virus (HBV) core promoter activity and transcription of HBV genes and production of HBV virions.
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Summary |
RNA-binding protein that acts as a mRNA splicing cofactor by promoting efficient splicing of transcripts that possess weak splice sites. Specifically promotes splicing of many cell-cycle and DNA-repair transcripts that possess weak splice sites, such as TUBG1, KATNB1, TUBGCP2, AURKB, PCNT, AKT1, RAD23A, and FANCG. Probably acts by facilitating the interaction between Serine/arginine-rich proteins such as SRSF2 and the RNA polymerase II. Also binds to DNA; binds to the consensus DNA sequence: 5'- GA[GT]AN[CG][AG]CC-3'. May indirectly repress hepatitis B virus (HBV) core promoter activity and transcription of HBV genes and production of HBV virions.
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Form |
Liquid |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
IHC-P, E
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Dilution |
ELISA (1:32000), IHC-P (5 μg/ml),
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Synonyms |
SON, C21orf50, DBP5, DBP-5, KIAA1019, NREBP, Protein SON, Protein DBP-5, SON DNA binding protein, NRE-binding protein, SON3, BASS1
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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