> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > ADAM17 / TACE Antibody (C-Terminus)Brand |
Leading Biology | Catalog Number |
APG01550G |
Product Type |
Polyclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality ADAM17 / TACE antibody (C-Terminus).
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Molecular Weight |
93kDa
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Cellular Localization |
Antigen Cellular Localization:
Membrane; Single-pass type I membrane protein
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Host |
Rabbit
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Species Reactivity |
Human
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Target |
synthetic peptide corresponding to C-terminal residues of human ADAM 17 (a disintegrin and metalloproteinase domain 17 isoform 1 preproprotein)
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Symbol |
CSVP, TACE
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GeneID |
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UniProt ID |
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Function |
Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called Notch extracellular truncation (NEXT). Plays a role in the proteolytic processing of ACE2.
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Summary |
Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called Notch extracellular truncation (NEXT). Plays a role in the proteolytic processing of ACE2.
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Form |
Liquid |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, IHC-P, E
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Dilution |
ELISA (1 μg/ml), IHC-P (20 μg/ml), WB (1 μg/ml)
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Synonyms |
Disintegrin and metalloproteinase domain-containing protein 17, ADAM 17, 3.4.24.86, Snake venom-like protease, TNF-alpha convertase, TNF-alpha-converting enzyme, CD156b, ADAM17, CSVP, TACE
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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