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GPR75 Antibody (C-Terminus)

Catalog # Availability Size / Price Inquiry
APR16598G 50 μg / $495

GPR75 Antibody (C-Terminus)

Brand

Leading Biology

Catalog Number

APR16598G

Product Type

Polyclonal Antibodies

Field of Research

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality GPR75 antibody (C-Terminus).

Molecular Weight

59kDa

Cellular Localization

Antigen Cellular Localization: Cell membrane; Multi-pass membrane protein

Host

Rabbit

Species Reactivity

Human, Rabbit, Hamster, Monkey, Pig, Chicken, Horse, Xenopus, Bovine

Target

Human GPR75. BLAST analysis of the peptide immunogen showed no homology with other human proteins.

GeneID

UniProt ID

Function

G protein-coupled receptor that is activated by the chemokine CCL5/RANTES. Probably coupled to heterotrimeric Gq proteins, it stimulates inositol trisphosphate production and calcium mobilization upon activation. Together with CCL5/RANTES, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. CCL5/RANTES may also regulate insulin secretion by pancreatic islet cells through activation of this receptor.

Summary

G protein-coupled receptor that is activated by the chemokine CCL5/RANTES. Probably coupled to heterotrimeric Gq proteins, it stimulates inositol trisphosphate production and calcium mobilization upon activation. Together with CCL5/RANTES, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. CCL5/RANTES may also regulate insulin secretion by pancreatic islet cells through activation of this receptor.

Form

Liquid

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Applications

IHC-P

Dilution

IHC-P (14 μg/ml)

Synonyms

Probable G-protein coupled receptor 75, GPR75

Images

Anti-GPR75 antibody APR16598G IHC of human eye, retina.

Specification

Quantity

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